Modeling hepatic osteodystrophy in Abcb4 deficient mice

Vitamin D modulates biliary fibrosis in ABCB4-deficient mice

PURPOSE Impaired vitamin D receptor signaling represents an aggravating factor during liver injury, and recent studies suggest that vitamin D might exert a protective role in chronic hepatobiliary diseases. We hypothesized that vitamin D supplementation would ameliorate liver fibrosis in ATP-binding cassette transporter B4 knockout (Abcb4 (-/-)) mice as a preclinical model of sclerosing cholang...

Hepatic Steatosis in ACE2-Deficient Mice

1Max Delbrück Center for Molecular Medicine, Berlin, Germany 2Laboratório de Reatividade Cardiovascular (LRC), Núcleo de Sı́ndromeMetabólica, Universidade Federal de Alagoas, Maceió, Brazil 3National Institute of Science and Technology in Nano-Biopharmaceutics (N-BIOFAR), Belo Horizonte, Brazil 4Departamento de Fisiologia e Farmacologia, Centro de Biociências (CB), Universidade Federal de Pernam...

Hepatic osteodystrophy and liver cirrhosis.

AIM To investigate the correlation between hepatic osteodystrophy and osteoporosis in patients with liver cirrhosis. METHODS Bone mineral density of the patients (n = 55) and that of the control group (n = 30) were measured by dual-energy X-ray absorptiometry. All the women in the study were premenopausal. Deoxypyridinoline, pyridinoline and urinary Ca(2+) were measured as bone destruction ma...

Hepatic osteodystrophy: vitamin D metabolism in patients with liver disease.

Hepatic osteodystrophy in rats results mainly from portasystemic shunting.

BACKGROUND AND AIMS In chronic liver disease, bone disease frequently develops. The contributions of the different features of liver disease such as parenchymal inflammation, portal hypertension, and portasystemic shunting on bone metabolism have not been systematically studied. The aim of this study was to identify the features of liver disease contributing to bone disease using rat models. ...